Treg cell abnormality and its potential treatments in patients with primary immune thrombocytopenia

Primary immune thrombocytopenia (ITP) is an autoimmune heterogeneous disorder. T regulatory cells (Treg), play important role in the pathogenesis of disease. Numerical and functional disorders Treg were both demonstrated ITP. Thymocyte output decrease instability contributed to lower count cells. Several deregulatory defects further led disease's onset. Restoring might have a therapeutic effect on New options focusing increasing number, or enhancing immunomodulating function was reviewed this manuscript.